ContraVir Pharmaceuticals Announces Publication of CRV431 Data from Experimental Model of Hepatitis B
“The research article reports our discovery that CRV431 greatly reduces HBV DNA in the liver of transgenic mice in a dose-dependent manner,” said Dr.
The article describes a study where Hepatitis B virus (“HBV”) transgenic mice were treated with CRV431, a cyclophilin inhibitor; and/or tenofovir exalidex (“TXL”), a nucleotide prodrug. Mice were treated daily for a period of 16 days receiving either 10 mg/kg of CRV431; 50 mg/kg of CRV431; 5 mg/kg of TXL; 10 mg/kg of TXL; a combination of 10 mg/kg of CRV431 and 5 mg/kg of TXL; or vehicle control. Key findings of the study include:
- CRV431 decreased liver HBV DNA levels dose-dependently, where the low (10 mg/kg/day) and high (50 mg/kg/day) doses of CRV431 reduced HBV DNA levels by 13% and 91%, respectively, compared to the vehicle group.
- TXL also decreased liver HBV DNA levels dose-dependently, where the low (5 mg/kg/day) and high (10 mg/kg/day) doses of TXL reduced HBV DNA levels by 55% and 97%, respectively, compared to the vehicle group.
- In mice that were co-dosed with the lowest tested doses of CRV431 (10 mg/kg/day) and TXL (5 mg/kg/day), liver HBV DNA decreased by 80% compared to the vehicle group.
The article may be accessed at: https://doi.org/10.1371/journal.pone.0217433.
ContraVir is a clinical stage biopharmaceutical company focused on the development of targeted therapies for liver disease arising from non-alcoholic steatohepatitis (NASH) and chronic hepatitis virus infection (HBV, HCV, HDV). The company’s lead drug candidate, CRV431, reduces liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of NASH. Preclinical studies also have demonstrated antiviral activities towards HBV, HCV, and HDV through several mechanisms. These diverse therapeutic activities result from CRV431’s potent inhibition of cyclophilin enzymes, which are involved in many disease processes. Currently in clinical phase development, CRV431 shows potential to play an important role in the overall treatment of liver disease - from triggering events through to end-stage disease. For more information, please visit www.contravir.com.
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Source: ContraVir Pharmaceuticals Inc.